of Active Hexose Correlated Compound (AHCC)
on Immobilization Stress in the Rat
Dokkyo J. Med. Sci.,
28(1), 559-565, 2001)
Shuyi Wang, Koji Wakame*,
Yoshihiko Igarashi, Ken-ichi Kosun*a and Shigeru Matsuzaki
Dokkyo Univ. School of Medicine, *Amino Up Chemical Co., Ltd.
AHCC, an extract from several basidiomycetes, has been
known as a biological response modifier (BRM) in humans as well
as in animals. In the present study, AHCC was tested for its ability
to modulate the hormonal responses to immobilization stress in
the rat. AHCC at 3% in drinking water was given to male Wistar
rats for one week, then rats were exposed to immobilization dor
1h. At 1h after immobilization, the serum levels of corticosterone,
noerpinephrine, epinephrine, dopamine and glucose were increased
significantly. Except for the corticosterone levels, all of these
changes were restored to control levels by the AHCC pretreatment.
These results suggest that AHCC can protect various effects induced
by immobilization by attenuating the sympathetic nerve activity.